Specifically, increased expression of CMKLR1 (OR = 1.16; 95% CI 1.09–1.23; P = 1.56e−06), FSTL1 (OR = 1.35; 95% CI 1.2–1.53; P = 1.05e−06), IGSF11 (OR = 1.62; 95% CI 1.35–1.94; P = 2.89e−07), and PIK3C3 (OR = 1.27; 95% CI 1.15–1.4; P = 1.08e−06) increased the risk of hyperparathyroidism, whereas elevated SLC40A1 (OR = 0.86; 95% CI 0.81–0.92; P = 1.31e−05) decreased the risk of hyperparathyroidism. This evidence concerns the gene FSTL1 and hyperparathyroidism.