PIK3C3 and hyperparathyroidism: Intriguingly, our analyses newly identify genotype–phenotype associations between PIK3C3 variants and altered hyperparathyroidism risk (eQTLGen odds ratio OR = 1.27, P = 1.08e−06; GTEx whole blood samples OR = 1.91, P = 1.53e−140; GTEx thyroid tissue OR = 1.25, P = 4.84e−27), strongly supported by colocalization (PPH4 = 0.933).