Our MR analysis suggested that SLC40A1, a mediator of Fe translating, may be a promising hyperparathyroidism therapeutic targets (eQTLGen odds ratio OR = 0.86, P = 1.31e−05; GTEx whole blood samples OR = 0.52, P = 1.23e−03; GTEx thyroid tissue OR = 0.75, P = 2.89e−137; PPH4 = 0.581). Here, SLC40A1 is linked to hyperparathyroidism.