In this study, we also found that several genes related to the inflammatory response, lymphocyte activation and innate immune response in the mucosa (Hp/Reg3g/Nupr1/Adam8/Cd55/Cfh/Ednrb) were upregulated in mice with EGFRL858R*PTEN-/- induced lung cancer. The gene discussed is EDNRB; the disease is lung cancer.