PTEN and lung cancer: In this study, we established an animal model of induced lung cancer, the EGFRL858R*PTEN-/- model, in which doxycycline treatment is used to induce the formation of a complex between TetO and scgb1a1-driven rtTA to express EGFRL858R and tamoxifen treatment is used to activate scgb1a1-driven Cre to cut the Lox P sites in the 5th exon of the PTEN gene, namely, its DNA binding motif (Fig. 1A).