SPAG16 and lung cancer: Indeed, the results indicated that PTEN knockout significantly increased the mRNA levels of most of the ciliated genes, namely, Cep126, Dcdc2a, Dnaic2, Dnah5, Foxj1, Hydin, Tctex1d4, Spag16, and Wdr63, implying that loss of PTEN may be involved in ciliogenesis during EGFRL858R-induced lung cancer progression (Fig. 3A).