Upon closer inspection, we observed that the degree of plasticity as measured by the ratio of the expression of the basal marker KRT5 to the luminal marker GATA3 (KRT5/GATA3) per cell was largely conserved across primary and metastatic UTUC within the same patient (Fig. 5f). Here, KRT5 is linked to renal pelvis/ureter urothelial carcinoma.