MYC and colorectal cancer: Our analysis highlights that while most β-catenin and H3K27ac loops are within the colorectal cancer MYC super-enhancer region and MYC gene body (Figure 6B, bottom panel), others can be found further upstream, connecting the super-enhancer over 2 Mb distance with a high probability β-catenin peak near the TAD boundary, implying that different β-catenin bound loci may have different functions.