Focusing on the TERTp-mutant glioma subtype, we developed an immune-related gene signature including HOXC6, WT1, CD70, and OTP that showed significant prognostic value for TERTp-mutant gliomas, but not for TERTp wild-type gliomas, in two TCGA cohorts. This evidence concerns the gene HOXC6 and central nervous system cancer.