We demonstrated that S100A7 was closely associated with the indicators of tumor heterogeneity (TMB, MATH, purity, HRD, and LOH) as well as those of tumor stemness (RNAss, DNAss, and EREG.EXPss) in multiple types of cancer, implying that S100A7 could play an important role in influencing these two features of tumors. The gene discussed is S100A7; the disease is neoplasm.