Finally, we obtained a GC prognostic risk model consisting of 14 parthanatos-related genes (SGCA, JAM2, SHISA3, DES, PDK4, SFRP2, GRP, TNC, PAEP, FBLN5, GLDC, CCDC80, HAND2, and PPP1R14A). This evidence concerns the gene SFRP2 and gastric cancer.