HAND2 and neoplasm: These genes were then used to construct a prognostic model for GC patients (SGCA, JAM2, SHISA3, DES, PDK4, SFRP2, GRP, TNC, PAEP, FBLN5, GLDC, CCDC80, HAND2, and PPP1R14A), Figure 3E shows the expression of 14 model genes in seven cell types of normal tissue, tumor tissue, and metastatic tissue (Figure 3E).