Several proteins that bind and regulate C-RAF have been identified, including RKIP (RAF1 kinase inhibitor protein), which functions as an anti-metastatic tumor suppressor and is down-regulated in various cancers (Yesilkanal & Rosner, 2018; Touboul et al, 2021; Cessna et al, 2022; Moghaddam et al, 2023). This evidence concerns the gene RAF1 and cancer.