It is well established in the literature that SIRT4 overexpression inhibits cell proliferation, among other cellular responses, in several tumor cell lines, most likely through inhibition of the MAPK pathway (Fu et al, 2017; Chen et al, 2019; Hu et al, 2019; Bai et al, 2020; Tomaselli et al, 2020; Wang et al, 2020). Here, SIRT4 is linked to neoplasm.