Interestingly, both NEUROG1 and NEUROD2 were hypermethylated and down-regulated in AT/RTs when compared to MBs in our DM-DE gene analysis and they harbor DMRs, which were hypermethylated in AT/RTs compared with PSCs and bound by BRD9 in rhabdoid tumors (Fig 4G). The gene discussed is NEUROD2; the disease is rhabdoid tumor.