This approach helped us to investigate whether DNA hypermethylation was mainly covering TFBSs in neural cells, so sites that are bound by the TF in (more) differentiated cells of the neural lineage, whether TF binding has been measured from the analyzed tumor types, and whether TFs are shown to bind to these sites already in PSCs that are expected to represent the earliest phases of (neural) cell differentiation. Here, TF is linked to neoplasm.