In the case of SMARCA4, these sites might represent SMARCA4 binding sites in rhabdoid tumors (significantly enriched in MB-hyper DMRs, Fig 2C), which have been DNA-methylated in an MB-specific manner, and they can potentially be also linked to the altered functions of the SWI/SNF complex in MBs in the context of BRG1 mutation (Yi & Wu, 2018). The gene discussed is SMARCA1; the disease is rhabdoid tumor.