In i450k data with a higher sample count, DNA methylation in DMRs was consistently higher in the AT/RT subgroups (MYC, SHH, and TYR) than in the subgroups of other tumor types (Wilcoxon rank sum test, P < 0.001, effect size Cliff’s delta |δ| > 0.2 for all comparisons except 0.18 for AT/RT-SHH versus PLEX, PED B and 0.13 for AT/RT-MYC versus PLEX, PED B) (Fig 1E, Table S1). Here, MYC is linked to neoplasm.