In addition, exosomes from mouse tumor LLC‐1 cells exhibited a similar dual positive and negative regulation in the STING signaling of RAW‐Lucia ISG cells (Figure S2H, Supporting Information).[32, 33] Taken together, these data demonstrate the dual function of A375 EXOs in the positive and negative regulation of the cGAS‐STING pathway—they assist 2′3′‐cGAMP in enhancing cGAS‐STING signaling, while exosomal ENPP1 hydrolyzes 2′3′‐cGAMP to inhibit the cGAS‐STING pathway. This evidence concerns the gene STING1 and neoplasm.