As an immuno‐transmitter, 2′3′‐cGAMP can be transported through a channel or by a transporter.[6, 7, 8, 9, 10, 11, 12, 13, 14, 15] Recent studies have shown that LL‐37, as an endogenous antimicrobial peptide, is an important intercellular transporter of 2′3′‐cGAMP to significantly activate cGAMP‐induced immune response.[15] We found that exosomes derived from various tumor cell types can impair 2′3′‐cGAMP‐mediated STING responses by hydrolyzing LL‐37‐2′3′‐cGAMP. This evidence concerns the gene STING1 and neoplasm.