To expand the role of ENPP1 in tumor immunotherapy, we characterized the modulation of immune cells by tumor cells that produced 2′3′‐cGAMP under stimulation of the chemotherapeutic drug cisplatin.[38] The combination of cisplatin (CP, 5 μM)[39] and STF‐1623 (300 nM) in A375, MDA‐MB‐231, and ENPP1‐overexpressed A375 cell types effectively enhanced the ISRE reporter activity of THP1‐Lucia ISG cells (Figure 4G; Figure S4F, Supporting Information). Here, ENPP1 is linked to neoplasm.