Therefore, we conclude that tumor‐derived exosomes play different roles in different modes of 2′3′‐cGAMP: both assist and degrade free 2′3′‐cGAMP to active or inhibit cGAS‐STING signaling pathways in a concentration‐dependance manner, yet only degrade LL‐37‐2′3′‐cGAMP to inhibit cGAS‐STING signaling pathways. The gene discussed is CGAS; the disease is neoplasm.