We first surveyed ENPP1 protein expression in primary skin cutaneous melanoma (SKCM), ductal carcinoma of the breast (DCIS), non‐small cell lung cancer (NSCLC), colorectal cancer (COAD), and glioma by immunohistochemical (IHC) staining experiments. The gene discussed is ENPP1; the disease is breast ductal adenocarcinoma.