ENPP1 and neoplasm: Moreover, our data reveal that all ENPP1‐carrying exosomes extracted from tumor tissues can effectively degrade 2′3′‐cGAMP (Figure 5C,D), which suggests that tumor‐derived exosomes are likely to hydrolyze 2′3′‐cGAMP in the tumor microenvironment by surface ENPP1 and dampen immune detection.