In summary, our work reveals a new mechanism by which tumor cells can secrete exosomes that carry ENPP1 to effectively hydrolyze 2′3′‐cGAMP and LL‐37‐2′3′‐cGAMP in the tumor microenvironment and, therefore, inhibit the cGAS‐STING pathway in immune cells (Figure 4H). Here, ENPP1 is linked to neoplasm.