Then, we treated ENPP1 knockdown tumor cells (A375, MDA‐MB‐231 and A549 ENPP1‐KD) with HT‐DNA (50 ng mL−1) and subsequently co‐cultured them with THP1‐Lucia ISG cells together with tumor‐derived exosomes treatment (Figure 4A). This evidence concerns the gene ENPP1 and neoplasm.