We took liposomes as the control exosomes.[31] The cGAMP‐induced ISRE reporter activities in THP1‐Lucia ISG cells revealed no statistically significant difference among treatments of incubating with either liposomes alone or in presence of STF1623 or ADP (Figure 2B; Figure S2G, Supporting Information), which highlights the important roles of tumor‐derived exosomes in regulating the cGAS‐STING signaling pathway. This evidence concerns the gene CGAS and neoplasm.