To evade immune surveillance, tumor exosomal ENPP1 can effectively hydrolyze extracellular 2′3′‐cGAMP or 2′3′‐cGAMP bound to LL‐37 (an effective transporter of 2′3′‐cGAMP) to inhibit cGAS‐STING pathway in immune cells. This evidence concerns the gene STING1 and neoplasm.