ENPP1 and neoplasm: LL‐37, as an antimicrobial peptide expressed by multiple cell types, has been shown to be an effective transporter of 2′3′‐cGAMP and can enhance the immune response of cGAS‐STING signaling.[15] Our study demonstrates also that tumor exosomal ENPP1 can effectively hydrolyze 2′3′‐cGAMP bound to LL‐37 to inhibit STING signaling in immune cells.