Indeed, in all the cell types that we have tested, we observed that various tumor‐derived exosomes can hydrolyze 2′3′‐cGAMP effectively, which suggests that (1) the hydrolysis of 2′3′‐cGAMP by tumor exosomal ENPP1 is not a cancer‐specific phenomenon and (2) all tumor‐derived exosomes carrying ENPP1 may have the function of hydrolyzing 2′3′‐cGAMP. The gene discussed is ENPP1; the disease is cancer.