ENPP1 and neoplasm: Meanwhile, the human host defense peptide LL‐37 has been reported to be an effective transporter of 2′3′‐cGAMP into target cells to activate STING signaling by binding with 2′3′‐cGAMP to form LL‐37‐2′3′‐cGAMP.[15] We further confirmed tumor exosomal ENPP1 also could hydrolyze 2′3′‐cGAMP in the form of LL‐37‐2′3′‐cGAMP (Figure 1H).