ICOS and neoplasm: Consistently, the upregulated genes in intra‐tumoral TLS‐high group (COL1A1, TGFB1, SPP1, CCR8, CCR3, CCL8, TNFRSF4, TNFRSF8, TNFRSF9, CD3D, IL2RG, CIITA, PDCD1, CTLA4, and ICOS) were highly enriched in tumor microenvironment‐related pathways (Figure 5B,C, adjusted P < 0.05).