Consistently, the upregulated genes in intra‐tumoral TLS‐high group (COL1A1, TGFB1, SPP1, CCR8, CCR3, CCL8, TNFRSF4, TNFRSF8, TNFRSF9, CD3D, IL2RG, CIITA, PDCD1, CTLA4, and ICOS) were highly enriched in tumor microenvironment‐related pathways (Figure 5B,C, adjusted P < 0.05). The gene discussed is COL1A1; the disease is neoplasm.