In contrast, genes upregulated in intra‐tumoral TLS‐low group were enriched in several hallmarks of cancer, such as protein translation (EIF3B, EIF2B4, EIF2B5), DNA repair (ERCC2, NME1, and POLR1C), oxidative phosphorylation (NDUFA1, NDUFA2, and NDUFA4), and mTOR signaling (RHEB, LAMTOR2, and MTOR) (Figure 5B,C, adjusted P < 0.05). This evidence concerns the gene NME1 and cancer.