It is well established that the shared p40 subunit of IL-12 and IL-23 can drive intestinal inflammation in several murine models of colitis.66,67 In the current study, however, the extent to which impaired Il12rb1 expression in cLP CD4+ T cells contributed to attenuated colitis in Il21r−/− mice was unclear. The gene discussed is IL12RB1; the disease is colitis.