BRD4 and non-small cell lung carcinoma: Moreover, SNHG18 exerts its prometastatic effects on non-small cell lung cancer cells through repression of miR-211-5p and induction of BRD4.33 If a similar mechanism underpinning miR-22-3p regulation by SNHG18 existed in VSMCs, we would have expected a down-regulation of miR-22-3p in SNHG18-overexpressing VSMCs since SNHG18 could decoy or suppress miR-22-3p.