IFNG and metabolic dysfunction-associated steatotic liver disease: The oxidative stress in NAFLD can induce alterations in the endothelial function occasioned by the formation and deposit of oxidized LDL; it has been determined that the administration of curcumin improves the histopathologic changes of NAFLD on reducing the levels of steatosis and that curcumin normalizes the numbers of serum aminotransferases because the treatment with curcumin [59] reduces oxidative stress, proinflammatory cytokines, IFN-γ, and IL-1β; on the other hand, it reduces the possibility of the progression of NASH to hepatocellular carcinoma [60].