The major risk factor for AMD is aging, and our data here as well as our earlier studies support an age-related accumulation of extracellular GzmB in the outer retina and choroid of older nonhuman primates and older human eyes; these findings confirm that the immunoreactivity for GzmB increases with age, thereby an important potential age-related factor in the pathogenesis of AMD [15, 23]. This evidence concerns the gene GZMB and age-related macular degeneration.