These criteria are the development of jaundice within the prior 8 weeks with serum bilirubin > 3 mg/dL, ongoing alcohol consumption (> 40 grams/day for females and > 60 grams/day for males) for ≥ 6 months within at least prior 60 days from onset of jaundice, aspartate aminotransferase (AST) to alanine aminotransferase ratio > 1.5 with both values < 400 IU/L and AST > 50 IU/L.5 The gene discussed is GPT; the disease is Jaundice.