RCAN1 and Dravet syndrome: The potential of EGCG to modulate gene expression in the Ts65Dn mouse model for DS has limited evidence, with one study administering 200 mg/kg EGCG on embryonic days 7 and 8 twice daily showing decreases in Protein patched homolog 1 (Ptch) and Ets2 RNA expression and significant increases in Rcan1 and Shh RNA expression in the first pharyngeal arch of Ts65Dn mice at embryonic day (E) 9.5 (McElyea et al., 2016).