In EGFR-mutant-dependent non-small cell lung cancer (NSCLC), first- or second-generation EGFR-TKI (e.g., gefitinib, erlotinib, afatinib, and dacomitinib) select for resistance due to the T790M point mutation (EGFR T790M) in 50% of patients [1–4]. Here, EGFR is linked to non-small cell lung carcinoma.