AHR and cancer: Numerous studies have shown that the physiological effects of AHR activation play a key role in tumorigenesis and immune regulation, and Mo et al. studied the gene expression data and clinical characteristics of 33 human cancers through the cancer genome database as a way to assess the prognostic value of AHR and found a strong correlation between AHR and immune cell infiltration and immune regulation, and high expression of AHR was significantly associated with immune-related pathways (21).