PolyQ expansion in ataxin-3 has not been associated with ALS risk, however a recent 3′untranslated region (3′UTR) alternative polyadenylation transcriptome-wide association study (3′aTWAS) discovered ATXN3 to be a 3′TWAS-significant gene for ALS [170]. The gene discussed is ATXN3; the disease is amyotrophic lateral sclerosis.