INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, several popular T2D drugs(such as insulin, thiazolidinediones, and derivatives of sulphonyl urea) increase body mass, which exacerbates insulin resistance.Type 2 diabetics who also have concurrent obesity have a much higher risk of several co-occurring conditions, especially those involvingthe cardiovascular system and chronic renal conditions [4].