In the cerebrospinal fluid (CSF) of AD patients, measurements of Aβ1–42 (Aβ42), total tau (tTau), and phosphorylated tau at Thr181 (pTau181) have proven useful in the early diagnosis of AD, which leads to their inclusion in diagnostic guidelines (Dubois et al., 2014, McKhann et al., 2011). Here, MAPT is linked to Alzheimer disease.