Hence, it could be hypothesized that CR may regulate the increased volume of the ventricular and CSF contributing to increased cerebral blood flow and the rapid flow of CSF, which improves the efficiency of amyloid clearance, as well as may relatively reduce the concentration of Aβ and tau protein in CSF, and thus resist cognitive impairment caused by high concentrations of Aβ and tau protein deposition. This evidence concerns the gene MAPT and Cognitive impairment.