HSD17B10 and early-onset autosomal dominant Alzheimer disease: According to the literature,the 17β-HSD10 overexpression may lead to the disturbance insteroid homeostasis proposed as an important factor attributing tothe development of various diseases, such as Alzheimer′s disease,5 prostate cancer,6,7 or osteosarcoma.8 Taken together, the restoration of steroid homeostasisthrough 17β-HSD10 inhibition is thought to promote neuroprotectionand serve as a promising therapeutic approach for the developmentof novel drug-like molecules.5,8,9