BAP1 and meningioma: For instance, rhabdoid meningiomas behave aggressively when they bear BAP1 gene mutations.5 Invasion of the adjacent gray matter is still regarded as unfavorable feature in CNS5 although this view is not uniformly accepted.6,7 The classification of meningiomas has been further implemented with the introduction of genome-wide DNA methylation arrays.8 A recent score that combines microscopic features, gene copy number variation, and epigenetic profile proved more accurate in the prognostic stratification of meningiomas.9