Li Q et al. investigated the role of ACT001 in glioblastoma cell lines, the study concludes that ACT001 directly binds to IKKβ and inhibits its phosphorylation also modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth [73]. The gene discussed is SOD2; the disease is glioblastoma.