It is generally endorsed as the most common signaling regulator for the instigation and progress of cancer, supporting tumor cell growth through the expression of several growth regulator genes like Cyclin-dependent kinase 2 (CDK2), cyclin D1, D2, D3, and cyclin E. Therefore, modulation of the NF-κB pathway can be a novel paradigm for fighting cancer [88]. Here, CCNE1 is linked to cancer.