Downregulation of cyclin B1 and cyclin D and tumor metastasis proteins MMP-9 and MMP-2 suggest that DMAMCL arrests the cell cycle at the G2/M stage, inhibiting the cell invasion and migration in HCC (LO2, Hepatoblastoma cell line (HepG2), Human hepatoma cell line (SMMC-7721), Human hepatoma cell line (Hep3B), Human hepatoma cell line (Huh7) cells [80]. Here, CCNB1 is linked to hepatocellular carcinoma.