In a randomized, double-blind, placebo-controlled parallel study, quercetin was tested on 84 women with an endocrine gland problem called polycystic ovary syndrome, which has multiple causes and is genetically complex, here quercetin partially increases the level of adiponectin by 5.56% as well as high molecular weight adiponectin by 3.9% as compared to the placebo, the resulting improvement in adiponectin-mediated insulin resistance [185]. The gene discussed is ADIPOQ; the disease is Insulin resistance.