For example, results from Evgeny and Wang et al. showed KRAS, TP53, and EGFR mutations played a dominant role in early invasive LUAD [18,36],while Zhang et al. highlighted the role of EGFR, ERBB2, and BRAF as early clonal genomic events in AIS, but TP53 was mainly found in MIA and IA [14]. Here, TP53 is linked to androgen insensitivity syndrome.