After adjustments for confounding variables, multivariate analysis revealed that in the entire cohort of 250 patients, CRP/Alb (HR = 0.471; p = 0.026), tumour differentiation (HR = 1.745; p <0.001), clinical T stage (HR = 1.513; p = 0.023), LNM (HR = 1.459; p = 0.042), and the combination of PF + CRP/Alb (HR = 8.034; p < 0.001) were independent factors significantly linked to OS. The gene discussed is ALB; the disease is neoplasm.