CD8A and neoplasm: As expected, CD8+ cells in the tumor were featured by the emergence of exhausted Tox-positive Tcf7−negative CD8+ T cells (TEX) accounting for about 50% of total CD8+ PD-1+ T cells in the tumor, whereas Tcf7−positive TSTEM subsets showed a strong distribution preference in the TdLN, with the Tcf7+ Tox+ TPEX population being the most abundant (Figure 3C).