Common genetic variation in the patatin-like phospholipase domain containing 3 (<i>PNPLA3</i>) and transmembrane 6 superfamily member 2 (<i>TM6SF2</i>) genes have been associated with an increased risk of developing NAFLD, nonalcoholic steatohepatitis (NASH), and fibrosis in adults. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.