NOS3 and atherosclerosis: Fluid shear stress and atherosclerosis signaling pathway can activate PI3K-Akt signaling pathway, generate eNOS, and release NO by exerting stable laminar shear stress on vascular endothelial cells, thus participating in atherosclerosis, vasoconstriction, inflammatory response, cell proliferation, and angiogenesis, etc (Cheng et al., 2023).