In the biochemical analyses, statistical significance is observed in the difference in parameters related to disease activity: albumin and complement C3 (p<0.001) were the lowest in the group with active LN, with slightly lower significance for C4 (p=0.002) between the two groups with LN, and for ANA and anti-ds DNA Ab, the expected statistically significant difference was obtained (p<0.001). The gene discussed is C4A; the disease is lobular neoplasia.