Adipocytes contribute to the secretion of proinflammatory cytokines such as TNF-α, IL-1β, MMP-2, MMP-9, IL-6, and MCP-1, as well as adipokines like adiponectin, which further contribute to chronic inflammation in adipose tissue of individuals with obesity [18]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.