After infection with rhinovirus in immature mice, an increase in the number of lung immune cells with upregulation of IL-13 was detected, which induced airway inflammation and mucus chemotaxis, and IFN-λ expression in the lungs was maintained at a high level 7 days after infection, suggesting that IFN-λ is associated with virus-induced Th2 immunity in the lungs (68). This evidence concerns the gene IL13 and infection.