ITGAM and Sjogren syndrome: 4-week-old NOD mice with absence of Sjögren’s Syndrome-like symptoms showed decreased percent of MDSCs (CD11b+Gr-1+) in blood compared with 8, 10, 12-week-old NOD mice, which showed progressive infiltration of T-cells in submandibular glands and gradual reduction in salivary flow rate (features that resemble Sjögren’s syndrome) (34), as well as increased levels of serum lL-12 (35).