In line with our expectations, combining the result of GSEA, IFN-related (IFN-α/β/γ signaling and response to viruses) genes, neutrophil-related (neutrophil degranulation and response to bacteria and fungi) genes, toll-like receptor (TLR), NOD-like receptor (NLR), RIG-I-like receptor (RLR) signaling pathways, and keratinization were significantly enriched in lesional skin, adequately explaining the molecular mechanism of psoriasis skin. Here, DHX58 is linked to psoriasis.