Here we utilized mice that express one copy of FLT3-ITD under the endogenous FLT3 promoter, have a homozygous loss of TET2 and a homozygous loss of p53 using Cre-mediated deletion of LoxP-flanked alleles (AML mice) (21, 28, 39, 40). The gene discussed is FLT3; the disease is acute myeloid leukemia.