CD4 and acute myeloid leukemia: It has been shown that mature DCs tune adaptive T cell responses into T-helper subsets (e.g. Th1, Th2, Th17, and Treg) (46–48) and given that the AML mice contain significantly increased levels of cDCs in vivo we hypothesized that CD4+ T cell populations would be altered systemically in the context of AML.