The frequency of circulating CD4+ T cells was not statistically different (Supplementary Figures 4G, H) but when we compared the canonical T-helper transcription factors T-bet, GATA3, FOXP3, and RORγt we found that in AML mice they had increased Treg and Th17 populations (Figure 4B). This evidence concerns the gene CD4 and acute myeloid leukemia.