Notably, upon examination of DC subtype proportions between WT and AML splenocytes, we observed a strong and significant shift in cDC2 subsets with AML splenocyte cDC2s being dominated by a Tbet- phenotype, while WT cDC2s maintained a Tbet+ phenotype (Figures 3D, E). The gene discussed is TBX21; the disease is acute myeloid leukemia.