On the other hand, patient 2 and 3 shared SNPs in NFKBIZ and in TNFAIP3, encoding the IL-17/TRAF6 signaling regulators IKB-ζ and A20, respectively, whose genetic variability could contribute to immune dysregulation and chronic inflammation in psoriasis lesions (60). The gene discussed is NFKBIZ; the disease is psoriasis.