However, although melanoma microenvironment can provide an optimal cytokine milieu for Th17 recruitment/expansion by expressing high IL-6 (36), and IFN-γ-releasing Th17 cells show antitumor effects through recruitment of cytotoxic CD8+ T cells (37), IL-17A-expressing cells were generally few around the primary melanoma lesions (38). The gene discussed is CD8A; the disease is melanoma.