KNG1 and cardiovascular disorder: Studies in cardiovascular disease and coagulation suggest that estrogen could affect BK expression at several levels, including by modulating FXII gene transcription, regulating the expression of the B2 receptor expression, and decreasing BK degradation through attenuation of APP activity.10, 11, 12 Therefore, the objective of this study was to investigate whether constituents of BK expression in plasma are modulated with administration of estrogen-containing oral contraceptive pills (OCPs).