Overall, 38 individuals were identified as having dGHD (n=32 with MRI abnormalities [n=18 reduced pituitary volume; n=7 empty sella; n=4 pituitary stalk interruption syndrome (PSIS); n=2 pituitary stalk thickening; n=1 pituitary agenesis]; n=5 with CPHD, 3 of whom had MRI abnormalities; n=2 with genetic diagnosis [pathogenetic mutations in GH1 gene]; n=2 with acquired damage secondary to brain radiotherapy). Here, GH1 is linked to empty sella syndrome.