Moreover, dGHD individuals with pathological retesting (2 with PSIS and 2 with CPHD) had significantly lower IGF-1 SDS (median -2.4 SDS [IQR -4.1;-1.5]) compared to those with normal retesting (median -1.0 [-1.9;-0.6]) (3 with empty sella, 2 with pituitary hypoplasia and 1 with a pathogenic mutation in the GH1 gene). This evidence concerns the gene IGF1 and empty sella syndrome.