In East Asians, however, the risk of elevated ALT (IVW: OR=0.9752, 95%CI, 0.9597-0.9909, p=0.0021; WM: OR=0.9734, 95%CI, 0.9528–0.9944, p=0.0133; MR-Egger: OR=0.9597, 95% CI, 0.9155-1.0060, p=0.0919; MR-PRESSO: OR=0.9752, 95%CI, 0.9597-0.9909, p=0.0031, Figure 3 and Supplementary Figure S2) and AST (IVW: OR=0.9673, 95%CI, 0.9528-0.9821, p=1.67e-5; WM: OR=0.9604, 95%CI, 0.9401-0.9811, p=0.0002; MR-Egger: OR=0.9401, 95%CI, 0.8994-0.9826, p=0.0080; MR-PRESSO: OR=0.9673, 95%CI, 0.9528-0.9821, p=5.74e-5; Figure 3 and Supplementary Figure S3) was found to decrease in patients with T2DM. Here, GPT is linked to type 2 diabetes mellitus.