AIF1 and Alzheimer disease: AD-like phenotypes, such as Iba-1 activation, amyloid-beta protein deposition, and spatial memory decline, were observed in 8-month-old endogenous melatonin reduced (EMR) mice, while FMT increased gut permeability, suppressed systemic inflammation, and alleviated AD-related phenotypes in the mice (Zhang et al., 2022a).