Bile acids (BAs) are closely associated with AD (Qian et al., 2021), where primary BAs (CA) are significantly decreased in AD patients, while secondary BAs and their conjugated forms (including DCA, GDCA, TDCA, and GLCA) are elevated (Mahmoudian Dehkordi et al., 2019; Alzheimer’s Association, 2019). Here, GNAT3 is linked to Alzheimer disease.