Hydrostatin-SN1 (H-SN1) peptide in the T7 phage library obtained from the venom of the snake Hydrophis cyanocinctus (H. cyanocinctus) by cloning system exhibits its anti-inflammatory effects through targeting TNFR and preventing the binding of TNF-α to TNFR in a murine model, resulting in alleviation of colitis symptoms. The gene discussed is TNF; the disease is colitis.