In a study by Yujie Sun and colleagues, it was shown that S. typhimurium engineered using Vibrio vulnificus (V. vulnificus) flagellin B (FlaB), which is a natural ligand of Toll-like receptor 5 (TLR5), strongly inhibits tumor growth and is an excellent aid for cancer immunotherapy [191]. The gene discussed is TLR5; the disease is cancer.