GM probiotics by expressing heat-shock proteins such as GroES and GroEL are able to tolerate stress in a wide range of temperatures [162], by delivery of therapeutic antimicrobial peptides (AMPs) are effective against antibiotic-resistant bacteria [163], and by targeting tumor cells and replication in the tumor site are useful to treat cancers exhibiting resistance to traditional cancer therapy [164]. This evidence concerns the gene HSPD1 and neoplasm.