Hu et al. (2020) found that the aryl hydrocarbon receptor (AhR) and its downstream regulators are highly expressed in the serum, PBMCs, and skin of AD patients and its correlation with disease severity (Hu et al., 2020). Nousbeck et al. (2022) analyzed the PBMC gene profile of infants with AD, revealing the molecular mechanisms and potential diagnostic markers of pediatric AD (Nousbeck et al., 2022). Here, AHR is linked to Alzheimer disease.