Merleev et al. (2022) analyzed RNA-seq datasets including GSE121212, and they found that PCSK9 is a psoriasis susceptibility locus that is negatively related to IL36G; this result established a putative link between PCSK9 and inflammatory cytokine expression (Merleev et al., 2022). Furthermore, PCSK9 has been reported to be associated with inflammation in AD (Valenzuela et al., 2020). The gene discussed is IL36G; the disease is Alzheimer disease.