Furthermore, reduced PV interneurons in SLITRK3 KO dentate gyrus could explain their hyperactivity and reduced anxiety-like behaviors because optogenetic activation of the dentate gyrus granule cells increases locomotive activity and open arm stayed time in elevated plus maze test (Kheirbek et al., 2013; Cho et al., 2022). The gene discussed is SLITRK3; the disease is Anxiety.