Experimental results show that in ovarian cancer, DOT1L regulates the transcription level of the SPARC gene by methylating the 79th lysine of histone H3 and that the SPARC protein promotes the adhesion of ovarian cancer cells 8; ovarian cancer cell invasiveness and vascular endothelial cell permeability increase when DOT1L expression is elevated. This evidence concerns the gene DOT1L and ovarian carcinoma.