CBX2 and colorectal carcinoma: Previous studies have reported that the phosphorylation level of MAPK may be regulated by Mettl3.14,25-27 Furthermore, it has been reported that Mettl3 expression level is drastically upregulated in CRC tissues in comparison with normal tissues, and knockdown of Mettl3 reduces the phosphorylation levels of ERK and p38 MAPK and inhibits CRC tumourigenesis and metastasis.16 Notably, our results confirmed that CBX2 KO in CRC cells caused a significant reduction in Mettl3 protein expression (Figure 5A), which could be rescued by the proteasome inhibitor MG132 (Figure 5B).