AKT1 and breast carcinoma: We found that proteins expression of CDC25C and p-AKT(T308) were significantly decreased in SK-BR-3 and MDA-MB-231 cells treated with LAS (1,3 μM) compared to that of controls, suggesting that LAS inhibited the phosphorylation of CDC25C and AKT via regulating PLK1 pathway in breast cancer cells.