PRKDC and nasopharyngeal carcinoma: In addition to the development and progression of NPC, a functional involvement of LINC00312 in NPC treatment was also noted, as this tumor suppressor was shown to improve the efficacy of radiotherapy in a xenograft mouse model of NPC by suppressing the phosphorylation of DNA-PKcs, a DNA-dependent protein kinase that is central to DNA double strand break repair 20.